The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase
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چکیده
منابع مشابه
The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase
We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Nature 2009, 459, 1146) of the AMPK homolog S. Pombe sucrose non-fermenting 1 (SNF1) has proposed a...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2011
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002082